Fig. 7
From: Liquid–liquid phase separation in human health and diseases
Phase separation in neurodegenerative disease. Schematic representation of brain areas containing pathological aggregates of four kinds of neurodegenerative diseases. This figure also summarizes disease-associated mutations and PTMs that decrease (red) or enhance (blue) LLPS compared with unmodified TDP-43, FUS, a-synuclein, or tau, as indicated. NTD: N-terminal domain, RRM: RNA-recognition motif, QGSY-rich: rich in glutamine, glycine, serine, and tyrosine, RGG: arginine/glycine-rich; ZnF, zinc finger; NLS, nuclear localization signal; NAC, non-Ab component of AD plaque; N1–2, polypeptide sequences encoded by exons 2 and 3; PRR, proline-rich regions; R1–4, microtubule-binding domains encoded by exons 9–12; p, phosphorylation; m, methylation; a, acetylation
