Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Dynamic landscape mapping of humoral immunity to SARS-CoV-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients

Fig. 4

Dynamic changes of antibody epitopes within SARS-CoV-2 proteases. a Longitudinal changes of IgM and IgG antibody epitopes identified within the SARS-CoV-2 nsp3 protein. b, c Structural analyses of IgM and IgG epitopes within the ADP ribose phosphatase and papain-like protease, respectively. d Longitudinal changes of IgM and IgG antibody epitopes identified within the SARS-CoV-2 nsp5 protein. e Structural analyses of IgM and IgG epitopes within the nsp5 protein. The epitopes within the functional domain that may interfere the protein activity are labeled in red. ADRP ADP-ribose phosphatase domain, PLpro papain-like protease domain

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