Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Dynamic landscape mapping of humoral immunity to SARS-CoV-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients

Fig. 5

Dynamic changes of antibody epitopes within the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). a–c Longitudinal changes of IgM and IgG antibody epitopes identified within the SARS-CoV-2 nsp7, 8, and 12 proteins, respectively. d–h Structural analyses of IgM epitopes on the RdRp complex, nsp8-RNA interaction interface, Thumb and Palm domain, Fingers domain, and N-terminal nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain, respectively. i–k Structural analyses of IgG epitopes on the RdRp complex, nsp8-RNA interaction interface, Fingers domain and NiRAN domain, respectively. The epitopes within the functional domain that may interfere the protein activity are labeled in red

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