Fig. 6

Dynamic changes of antibody epitopes within the SARS-CoV-2 nsp10/nsp16 2′-O-methylase complex. a, b Longitudinal changes of IgM and IgG antibody epitopes identified within the nsp10/nsp16 2′-O-methylase complex, respectively. c, d Structural analyses of IgM and IgG epitopes within the nsp10/nsp16 2′-O-methylase complex. The epitopes within the functional domain that may interfere the protein activity are labeled in red