Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma

Fig. 5

a Schematic of the in vitro BBB model by Transwell assays; b Immunofluorescence staining of the endothelial cell interstitial protein ZO-1 (green); nuclei (blue); c TEER value of the in vitro BBB model for 7 consecutive days; d The fluorescence intensities of the Cy7-SPIONs, ANG/Cy7-SPIONs, and DANG/Cy7-SPIONs probe solutions passing through the upper chamber of the Transwell unit. Data from at least three independent experiments are shown as the means ± SEMs, n = 3

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