Fig. 8 | Signal Transduction and Targeted Therapy

Fig. 8

From: Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma

Fig. 8

a In vivo images of tumour-bearing mice injected with Cy7-SPIONs, b ANG/Cy7-SPIONs, and c DANG/Cy7-SPIONs probes which were conducted with an IVIS imaging system. Images of glioma-containing brain slices from mice injected with d Cy7-SPIONs, e ANG/Cy7-SPIONs, and f DANG/Cy7-SPIONs which was conducted with an automated quantitative pathology imaging system. g–i The images in the lower showed a ×2 magnification of the areas in the yellow boxes in the images above. The border of the glioma is highlighted by the white dotted line. The DAPI signal in blue indicates cells, and the Cy7 signal in red indicates probes. j Ex vivo NIR fluorescence images of three probes in tumour-bearing brains after intravenous injection for 24 h. The upper images are MRI images showing tumour size; the lower images are NIR fluorescence images showing the fluorescence signal of the probes; k The total intensity of the three probes in tumour-bearing brains. Data from at least three independent experiments are shown as the means ± SEMs, n = 3, *p < 0.05

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