Fig. 4
From: Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies
Viral RNA is transcribed to become polyproteins. Mpro and PLpro function as a knife, cutting the polyproteins translated from the viral RNA and forming functional viral proteins (Nsp1-16). SCoV2-PLpro also cleaves the ubiquitin-like interferon-stimulated gene 15 protein (ISG15) and reduces type I interferon to further affect host immune response. The development of anti-SARS-CoV-2 drug would undergo four steps: (1) screening thousands of antiviral compounds in database; (2) structure-based viral selecting; (3) preclinical study; and (4) clinical study
