Fig. 3: 3E8 blocked the infections of ACE2-expressing cells by multiple pseudo-typed coronaviruses.
From: ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker

ACE2-Fc and B38 were used as positive controls, and human IgG4 isotype was negative control. a–g 3E8 blocked infections of ACE2-overexpressing HEK293 cells by different pseudo-typed coronaviruses with Env-defective HIV-1 and full-length S-proteins from SARS-CoV-2, SARS-CoV-2-D614G, B.1.1.7, B.1.351, B.1.617.1, SARS-CoV, and HCoV-NL63. h The IC50 values of 3E8 in blocking pseudo-typed coronaviruses