Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Melatonin enhances radiofrequency-induced NK antitumor immunity, causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development

Fig. 4

MLT promotes the viability and proliferation of NK cells and enhances the phagocytic ability of NK cells. a MLT promotes the viability and proliferation of NK cells. The cell vitality of NK92 cell after treatment with different concentrations of MLT for 24 h (0, 1, 2 mM) and the cell number was counted using Cellometer Auto T4 Cell Counter (*P < 0.05). b In vitro cytotoxicity of NK92 cells in co-culture with K562 cells at the indicated E:T ratios (1:1, 2:1, 5:1) with different concentrations MLT via CCK8 assay. c Representative fluorescence images and the bar graphs of MLT-treated NK cells in co-culture with K562 at different effector:target ratios for 24 h (scale bar = 50 μm). (*P < 0.05; **P < 0.01; ***P < 0.001)

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