Table 1 The frequency of KRAS mutations in cancer
From: KRAS mutation: from undruggable to druggable in cancer
KRAS mutations (%) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Tumour types | Sample | Total rate | Mutation sites | Top 1 | |||||
G12 | G13 | Q61 | A146 | Other | |||||
Pancreatic adenocarcinoma | 1207 | 67.61 | 62.30 | 0.83 | 4.23 | 0.08 | 0.17 | G12D | 26.84 |
Colorectal adenocarcinoma | 3953 | 35.77 | 22.82 | 6.68 | 1.67 | 2.76 | 1.85 | G12D | 9.87 |
Nonsmall-cell lung cancer | 7135 | 20.42 | 17.39 | 0.85 | 0.31 | 0.06 | 1.81 | G12C | 8.38 |
Cholangiocarcinoma | 1072 | 12.69 | 8.96 | 1.12 | 1.12 | 1.87 | 0.37 | G12D | 4.29 |
Uterine endometrial carcinoma | 1907 | 14.11 | 10.38 | 1.78 | 0.63 | 0.10 | 1.21 | G12D | 4.20 |
Testicular germ cell cancer | 506 | 11.66 | 6.92 | 0.00 | 1.98 | 1.58 | 1.19 | G12V | 2.77 |
Cervical squamous cell carcinoma | 607 | 4.28 | 2.47 | 0.99 | 0.00 | 0.49 | 0.33 | G12D | 1.32 |
Myelodysplastic | 6940 | 3.83 | 1.86 | 0.75 | 0.29 | 0.23 | 0.71 | G12D | 0.84 |
