Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice

Fig. 3

The VEEV-VRP-CB6 treatment could protect cells against SASR-CoV-2 infection. a Vero-E6 cells were treated with VEEV-VRP-CB6 or VEEV-VRP-eGFP at the MOI of 10 or DMEM. After 24 h, the transduced cells were infected with SARS-CoV-2 at an MOI of 0.01, and 24 h later, the cells were fixed and stained for SARS-CoV-2 NP protein (green) and CB6 mAb (red), respectively. Nuclei were stained with DAPI (blue). Scale bars represent 50 μm. b Percentages of SARS-CoV-2 NP positive cells and CB6 mAb positive cells in each group of cells. The ratios of SARS-CoV-2 NP or CB6 mAb positive cells were calculated by division with cell numbers stained with DAPI from three microscopy images which were captured from different view of each sample, and the error bar represent standard deviations

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