Fig. 7 | Signal Transduction and Targeted Therapy

Fig. 7

From: FSAP aggravated endothelial dysfunction and neurological deficits in acute ischemic stroke due to large vessel occlusion

Fig. 7

FSAP regulates endothelial function by Wnt5a signaling. a The top 15 KEGG enriched pathways of the 38 selected genes. b, c The Heatmap image depicting transcriptional changes of the members of Wnt signaling pathway in different (b) groups, and c RT-qPCR validations. Data is expressed as mean ± SD; n = 5–7 for each group; n.s. not significant, **p < 0.01, ***p < 0.001 versus Control group, n.s. not significant, #p < 0.05, ##p < 0.01, ###p < 0.001 versus vehicle group by one-way ANOVA followed by Tukey’s multiple comparison tests. d, e Pro-angiogenic factors expression was detected by Western blot. d Representative Western blot images and e quantitative analysis. Data is expressed as mean ± SD; n = 6–8 for each group; n.s. not significant, *p < 0.05, ***p < 0.001 versus control group, n.s. not significant, #p < 0.05, ##p < 0.01, horizontal lines and corresponding hashes compare samples aligned with each end of the horizontal line by one-way ANOVA followed by Tukey’s multiple comparison tests. f Quantitative analysis of migration cells, proliferative cells, branch length, branch counts, and junction counts. Data is expressed as mean ± SD; n = 6–8 for each group; n.s. not significant, *p < 0.05, ***p < 0.001 versus Control group, n.s. not significant, #p < 0.05, ##p < 0.01, horizontal lines and corresponding hashes compare samples aligned with each end of the horizontal line by one-way ANOVA followed by Tukey’s multiple comparison tests

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