Fig. 8 | Signal Transduction and Targeted Therapy

Fig. 8

From: FSAP aggravated endothelial dysfunction and neurological deficits in acute ischemic stroke due to large vessel occlusion

Fig. 8

Take home figure. Plasma FSAP levels significantly increased in patients with AIS due to LVO and poor collaterals, and correlates with neurological outcome. Pathological expression of FSAP was validated in an experimental stroke model, and negatively associated with pro-angiogenic vascular factors. Suppression of FSAP enhances revascularization, improves the integrity of brain blood barrier, and promotes newly formed microvessels in the penumbral area of ischemic brains, and consequently decreased infarct size and neurological deficit. Mechanistic analysis revealed FSAP might facilitate endothelial dysfunction by regulating Wnt5a signaling

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