Fig. 2

Changes in Hb, transfusion volume, and Hb F in patients upon placebo or thalidomide treatment. The levels of Hb (a, b) and transfusion volume (c) were expressed as mean ± standard deviation (SD), and P values determined by Student’s t test (*) and mixed-effects regression analyses (#) were provided. ***P < 0.001, ****P < 0.0001; ####P < 0.0001. The percentages of Hb F (d) were expressed as median (interquartile range), and P value was determined by Mann–Whitney U test. $$$P < 0.001