Fig. 4

The measurements of secreted metabolic factors in sera of COVID-19 patients. a The heatmap is shown to represent the alteration of secreted metabolic factors in non-severe infection, non-severe recovery group, severe infection, and severe recovery group against the healthy control group. Data are shown as log₂ fold change, values of metabolic factors in the healthy control group were set as 0. Sera myeloperoxidase (b), apelin (c), myostatin (d), fibroblast growth factor 21 (FGF21) (e), bone morphogenetic protein 7 (BMP7) (f), and growth differentiation factor 15 (GDF15) (g) in healthy control (n = 10), non-severe infection (n = 29), non-severe recovery group (n = 29), severe infection (n = 5), and severe recovery group (n = 5) are shown. h The heatmap is shown to represent the correlation between myeloperoxidase, apelin, and myostatin and metabolic parameters. Data are shown as R-square. Error bars represent SEM. *P < 0.05; **P < 0.01. See also Supplementary Fig. S4