Fig. 12
From: An overview of kinase downregulators and recent advances in discovery approaches
Engineered Ba/F3 kinase cells for kinase inhibitor selectivity and activity profiling. Ba/F3 cells are rendered IL-3-independent and kinase-dependent by introducing a kinase gene in Ba/F3 cells through a genetic engineering approach. The activity of the kinase inhibitor can be evaluated by cell viability of kinase-Ba/F3 cells after inhibitor treatment
