Fig. 6
From: An overview of kinase downregulators and recent advances in discovery approaches
The four types of allosteric kinase inhibitors. Allosteric inhibitors bind to allosteric pockets that are adjacent to the ATP pocket, but do not overlap with the ATP-binding pocket, which is defined as type III inhibitors. The binding pockets are distant from the ATP-binding pocket; these kinds of small molecules are defined as type IV inhibitors. Small molecules that bind the pseudokinase domain (JH2) are defined as type VI inhibitors and these bind the extracellular domain (ECD), which are defined as type VII
