Fig. 7
From: An overview of kinase downregulators and recent advances in discovery approaches
The binding mode of trametinib with MEK1 (PDB: 7M0Y). Trametinib binds with MEK1 in type III binding mode at the allosteric pocket next to the ATP pocket and forms five hydrogen bonds with Asp208, Phe209, Gly210, Val211, Ser212, and Ile216
