Table 2 A comparison of target-based and phenotypic approaches
From: An overview of kinase downregulators and recent advances in discovery approaches
Target-based drug discovery (TDD) | Phenotypic drug discovery (PDD) | |
|---|---|---|
Target | Known | Unknown |
Cost | Low | High |
Speed | Rapid | Moderate |
Ease of SAR | Easy | Difficult |
Characteristics of drug | Best-in-class | First-in-class |
Clinical translatability | Lower (depends on other evidence) | Presumed to be higher in general |
