Table 1 Different effectors of class I, II and III PI3Ks
From: Targeting PI3K/Akt signal transduction for cancer therapy
PI3K isoforms | Effectors | References | |
|---|---|---|---|
Class I PI3K | Serine/Threonine kinases of the AGC kinase family | AKT | |
PKC | |||
PDK-1 | |||
SGK1 | |||
Tyrosine kinases of the TEC family | BTK | ||
BMX | |||
ITK | |||
Guanine nucleotide exchange factors (GEFs) | Rac | ||
P-Rex1 | |||
Tiam1 | |||
Vav1 | |||
Vav2 | |||
Class II PI3K | Sortins | ||
Small GTPase | |||
Myotubularins | |||
Class III PI3K | LKB1 | ||
SGK3 | |||
