Table 3 Current inhibitors targeting Akt signaling in cancer
From: Targeting PI3K/Akt signal transduction for cancer therapy
Inhibitor | Phase | Target | ClinicalTrials.gov Identifier: | Reference |
|---|---|---|---|---|
Perifosine | II | AKT1/2/3 | Â | |
GSK-690693 | I | AKT1/2/3 | Â | |
VQD-002 | I | AKT1/2/3 | Â | |
AZD-5363 | III | AKT1/2/3 | NCT04493853 | Â |
GDC-0068 | III | AKT1/2/3 | NCT04650581 | Â |
GSK-2141795 | II | AKT1/2/3 | NCT01964924 | Â |
M2698 | I | AKT1/3 | Â | |
GSK-2110183 | II | AKT1/2/3 | NCT01531894 | Â |
MK-2206 | II | AKT1/2/3 | NCT01370070 | Â |
