Fig. 1

Genomic landscape of 40 pairs of primary and early-recurrent HCCs. a A concise diagram of the sequencing research in the present HCC genomic study. b The number of somatic mutations (SNVs + indels) in the whole genome across 40 pairs of primary and early-recurrent HCCs. c The number of structural variations (SVs) in 40 pairs of primary and early-recurrent HCCs, including insertions, inversions, tandem duplications, deletions, and inter- and intra-chromosomal translocations. d GISTIC analysis revealed the whole-genome distribution of copy-number alterations in paired primary (left panel) and early-recurrent (right panel) HCCs. GISTIC q-values (y-axis) for amplifications (upper, red) and deletions (lower, blue) are plotted across the genome (x-axis). e The genomic alteration of driver genes in 40 pairs of primary and early-recurrent HCCs, identified through whole-genome sequencing. Drivers present in ≥4 patients are shown. All mutations (SNVs + indels) were validated by Sanger sequencing