Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: MEOX1: a novel druggable target that orchestrates the activation of fibroblasts in cardiac fibrosis

Fig. 1

a Schematic step-by-step overview of the mechanisms leading from cardiac injury to activation of pro-fibrotic gene expression in fibroblasts, as depicted by Alexanian et al. Sites of experimental interference used to clarify critical regulatory elements are highlighted. (heart graphic source: smart.servier.com) b Single-cell RNA expression of MEOX1, including 24 different organs of origin. The figure was generated using the single-cell dataset from the tabula sapiens consortium6

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