Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: LncRNAs LCETRL3 and LCETRL4 at chromosome 4q12 diminish EGFR-TKIs efficiency in NSCLC through stabilizing TDP43 and EIF2S1

Fig. 1

LCETRL3 and LCETRL4 are two significantly upregulated lncRNAs in NSCLC specimens. (a) Five candidate lncRNAs (LCETRL1, LCETRL2, LCETRL3, LCETRL4 and LCETRL5) locate at 4q12. (b) Relative expression of five candidate lncRNAs in paired NSCLC and normal tissues of Discovery cohort (n = 20). (c, d) Significantly elevated expression of lncRNAs LCETRL3 and LCETRL4 in NSCLC specimens of Validation cohort (n = 44) and TCGA lung cancer tissues compared to normal tissues. Two-tailed paired t test or two-tailed unpaired t test, n.s., not significant, *P < 0.05, **P < 0.01, ***P < 0.001

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