Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: LncRNAs LCETRL3 and LCETRL4 at chromosome 4q12 diminish EGFR-TKIs efficiency in NSCLC through stabilizing TDP43 and EIF2S1

Fig. 2

LncRNAs LCETRL3 and LCETRL4 suppressed malignant proliferation of NSCLC cells in vitro and in vivo. (a–c) Silencing of LCETRL3 with shRNAs inhibited proliferation of PC9 and H1299 cells; whereas overexpressed lncRNA LCETRL3 promoted proliferation of NSCLC cells. (d) LCETRL3 promoted clonogenicity of PC9 and H1299 cells. (e–g) Knocking-down of lncRNA LCETRL4 with shRNAs inhibited proliferation of PC9 and H1299 cells. On the contrary, overexpression of LCETRL4 promoted viability of NSCLC cells. (h) LCETRL4 stimulated colony formation of PC9 and H1299 cells. (i–k) In vivo growth of NSCLC xenografts was promoted by lncRNA LCETRL3 or LCETRL4. Two-tailed unpaired t test, **P < 0.01, ***P < 0.001

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