Fig. 1: SARS-CoV-2 induces mast cell degranulation and lung injury in hACE2-humanized mice. | Signal Transduction and Targeted Therapy

Fig. 1: SARS-CoV-2 induces mast cell degranulation and lung injury in hACE2-humanized mice.

From: SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury

Fig. 1

Five C57BL/6N-Ace2em2(hACE2-WPRE,pgk-puro)/CCLA mice were intranasally infected with SARS-CoV-2 (strain 107) at a dose of 2 × 106 TCID50, two mice were used as the mock-infections. The mice were euthanized at the 1 dpi, 3 dpi and 5 dpi, and the lung tissues were harvested for histological analysis. Toluidine blue staining was used to observe MCs and their degranulation (a, c, e and g), and the lung injury was observed by H.E. staining (b, d, f and h), scale bar: 100 μm. (i) The pathological score was assessed according to the degree of lung tissue lesions and MC count in lung sections was calculated. *p < 0.05 and **p < 0.01 are considered significant differences

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