Fig. 3: SARS-CoV-2 induces mast cell degranulation in aged chRMs. | Signal Transduction and Targeted Therapy

Fig. 3: SARS-CoV-2 induces mast cell degranulation in aged chRMs.

From: SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury

Fig. 3

Aged chRMs (17- to 19-year old) were anaesthetized by Zoletil 50 and intratracheally inoculated with SARS-CoV-2 (1 × 107 TCID50) in a 2 mL volume by bronchoscope. a Mock infection. The animals were euthanized at 7 dpi (b) or 15 dpi (c, d) and the lung lobes were collected for histology analysis. Toluidine blue staining was used to observe MCs and their degranulation. Red arrow indicates the MCs

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