Fig. 3: Hyper- and hypo-methylation events across ESCC and integrated profiling of ESCC driver genes.

a Map overview of genetic and epigenetic alterations in 20 ESCC driver genes previously identified. ach column denotes an individual patient and each row represents the status of one gene including somatic mutations (black squares), copy number amplifications (red bars), copy number deletions (blue bars), hyper- (pink bars) and hypo-methylated events (azure bars). Wild-type cases are in gray. Right, percentage of alterations for each gene in 91 ESCC patients while the X axis represents total percentage of alterations for each gene. b, c We tested recurrent genetic alterations in ESCC for their associations with frequency of hyper- (b) or hypo-methylated event (c). Significant associations (Wilcoxon P < 0.05) were shown in above and labeled by gene symbol for somatic mutations or cytoband for amplifications and deletions. Each column denotes an individual patient and each row is one genetic alteration including somatic mutations (black bars), copy number amplifications (red bars) and copy number deletions (blue bars). Wild-type cases are in gray. Top color bars represent the frequency of DNA methylation