Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients

Fig. 5

Lipidomic and metabolomic profiling of sera from infected minks at 6 dpi compared with that of control at 0 dpi. a Volcano plot showing the relative content differences of metabolites between minks at 0 and 6 dpi and the significance of statistical differences. Each dot in the volcano plot represents a metabolite, with green dots representing downregulated differential metabolites, red dots representing upregulated differential metabolites, and gray dots representing metabolites detected but not significantly different. b Cluster heatmap of differential lipidome. CE cholesterol ester, DG diacylglycerides, TG triglycerides, FA fatty acid, FFA free fatty acids, PC phosphatidylcholine, LPC lysophosphatidylcholine, PE phosphatidylethanolamine, LPE lysophosphatidyl ethanolamine, LPG lysophosphatidylglycerol, PI phosphatidylinositol, PS phosphatidylserine, LPO lipid peroxide. c Cluster heatmap of the differential metabolome. d Bar chart and radar map of differential lipidome. e Bar chart and radar map of differential metabolites. f Serum concentrations of six steroids. *P < 0.05, **P < 0.01. Data are presented as mean ± standard deviation with individual data points shown

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