Fig. 6
From: Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing
Off-target analysis for RNA editing in vivo by RNA-Seq. a Off-target-1 to Off-target-10 were ten off-target sites detected by RNA-seq. Mismatches compared to the on-target site are shown and highlighted in color. The 30 bp sequence (On-target) targeted by the sgRNA3 is shown in the top row. b Comparison of FPKM values of the ten off-target sites at injected AAV-CasRx + sgRNA3 or non-injected ears. Data are shown as the mean ± SD. ns no significance. Statistical analysis was performed by multiple unpaired t-test
