Fig. 3
From: Molecular regulations of circadian rhythm and implications for physiology and diseases
Protein–protein interaction (PPI) network between the core clock components and clock-related proteins. STRING Protein–Protein Interaction database (Ver 11.5)147 has been used to build the PPI network. The network contains 48 nodes and the edges represent the crosstalk between the core clock components and proteins belonging to other key intracellular pathways. Line thickness reflects the strength of data support for protein-protein interaction that derives from databases, experiments, or based on computational predictions. The network is clustered based on a specified “MCL inflation parameter” and on a customized clustering coefficient of 0.300. The different biological processes investigated are shown in the network according to the color legend
