Fig. 1
From: Omicron adopts a different strategy from Delta and other variants to adapt to host
Omicron adopts a different strategy from Delta and other variants to adapt to host. a Expression of variants S proteins in 293T cells. b, c The infectivity of variants pseudovirus in 293T-ACE2 after indicated time of incubation at 37 or 42 °C. d The infectivity of variants pseudovirus in several cell lines. e The infectivity of variants pseudovirus in 293T-ACE2 transiently overexpressed with TMPRSS2/11D/11F/13. f, g The infectivity of variants pseudovirus in 293T/Caco2-ACE2-TMPRSS2 cells pretreated with E64d (5 μM) or/and Camostat (50 μM) for 2 h. h The dynamic of cell–cell fusion mediated by ACE2 and variants S proteins. i The NF-κB reporter activation mediated by incubation with variants S proteins expressing 293T cells. j, k The neutralization of variants pseudovirus by sera from 14 volunteers received two doses of inactivated SARS-CoV-2 vaccines. The numbers indicate change of geometric mean titers compared with D614G reference virus. l The neutralization of variants pseudoviurs by 10 mNAbs targeting RBD of S protein. BDL indicates neutralizing activity below the detection limit when tested at the highest concentration. m The radar chart of characters of variants. Experiments were done in 3–4 replicates and repeated at least twice. One representative is shown with error bars indicating SEM
