Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Three doses of prototypic SARS-CoV-2 inactivated vaccine induce cross-protection against its variants of concern

Fig. 2

Cellular immune responses induced by vaccination of the prototypic SARS-CoV-2 inactivated vaccine in rhesus monkey. a The representative dot and contour plots showed populations of total T cells, CD4 + T cells, CD8 + T cells, B cells and monocytes from a rhesus macaque. Firstly, singlets were gated to eliminate doublets and then gating was performed on the indicated subsets of lymphocytes. Then combination of cell type-specific markers was used to define immune cells, such as CD45 + CD3 + for total T cells that were further differentiated by CD4 and CD8 markers, CD45 + CD3-CD16-CD20 + to determine total B cells and CD45 + CD3-CD16-CD20- for NK cells with activation marker CD80, CD45 + CD14 + CD16- for monocytes with activation marker CD86. b Mean frequencies of each subsets of immune cells are shown as curve plots (each plot represents one animal with the red line for unvaccinated animals and the blue line for vaccinated animals)

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