Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Three doses of prototypic SARS-CoV-2 inactivated vaccine induce cross-protection against its variants of concern

Fig. 4

Vaccination of prototypic SARS-CoV-2 inactivated vaccine mitigated the pathological changes in the pulmonary tissues of VOCs infected animals. Rhesus monkeys (vaccinated or unvaccinated) were inoculated i.n/i.t with 1 ml of 106 pfu respective variants as indicated. On 7 dpi, all animals were euthanized and dissected. Lung tissues were harvested and prepared for H&E staining and further histological analysis by experienced pathologists (a). According to the severity of histological lesion, pathological score was given to each tissue sample (b). The pathological changes were obviously alleviated in the vaccinated animals infected with variants

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