Fig. 2
From: Signaling pathways and targeted therapy for myocardial infarction
a PI3K/Akt signaling pathway and targeted therapy in Myocardial infarction (MI). PI3K/Akt is involved in the regulation of cardiac remodeling, regeneration, and repair post-ischemia. This pathway responds to the stimulus, likewise growth factor/growth factor receptor signaling and so on. Phosphorylated PI3K and Akt activate the downstream molecules, VEGF, eNOS, while inhibiting mTOR(C1), GSK-3β, FOXO, respectively. GF, growth factor; GFR growth factor receptor, PI3K Phosphoinositide-3 kinase, Akt protein kinase B, PIP2 phosphatidylinositol 4,5-bisphosphate, PIP3 phosphatidylinositol 3,4,5-trisphosphate, PDK phosphoinositide dependent kinase, PH Pleckstrin homology, PTEN phosphatase and tensin homolog, VEGF vascular endothelial growth factor, eNOS endothelial nitric oxide synthase, mTORC1/2 mammalian target of rapamycin complex 1/2, GSK-3β glycogen synthase kinase 3β, FOXO forkhead box subfamily O, AZIN2-sv lncRNA-AZIN2 splice variant, S1P sphingosine-1-phosphate, Ezh2 enhancer of zeste homolog 2. b Notch signaling pathway and targeted therapy in MI. RBP-JК recombination signal-binding protein-JК, NICD notch intracellular domain, CSL CBF1/Rbpj (mammalian), Su(H) (Drosophila), and Lag-1 (Caenorhabditis elegans), CX Chuanxiong, CS Chishao VA velvet antler, YQHX Yiqihuoxue prescription, AGS astragaloside
