Fig. 2
The plasma level of hyaluronan as a typical indicator of COVID-19 patients in the clinical setting. a C-reactive protein of COVID-19 patients is showing based on the threshold of 48.43 ng/mL of hyaluronan. b The relation of C-reactive protein against hyaluronic acid was determined by two-tailed Spearman’s correlation analysis. c D-dimer of COVID-19 patients is showing based on the threshold of 48.43 ng/mL of hyaluronan. d The relation of D-dimer against hyaluronic acid was determined by two-tailed Spearman’s correlation analysis. e Fibrinogen of COVID-19 patients are showing based on the threshold of 48.43 ng/mL of hyaluronan. f The relation of fibrinogen against hyaluronic acid was determined by two-tailed Spearman’s correlation analysis. Data in (a, c, and e) are presented by mean ± SD. The significant difference was confirmed by the Mann–Whitney test. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; ns, not significant
