Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD

Fig. 5

Interactions of 35B5 Fab with RBD. a Mutations in the RBD of reported SARS-CoV-2 variants of concern or interest. b–g The residues E484 (b) and L452 (d) are not involved in the interactions of RBD with 35B5 Fab. E484 is more than 4.2 Å away from 35B5 R84, which forms cation–π interaction with RBD F490. The E484K mutation in RBD does not interact with 35B5 R84 through molecular modeling (c). The L452Q modeling suggests none interactions formed at this site with 35B5 (f). In structural modeling, the L452R mutation (e) and F490S mutation (g) in RBD generate potential additional interactions with 35B5 Fab. Potential hydrogen bonds are shown as dashed lines

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