Fig. 4
From: LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB)
IETP2 delivers the small-molecule curcumin (Cur) across BLB. a Schematic representation of the structure of IETP2-Linker-Cur. Two Cur molecules were attached to one peptide molecule. The red ribbon represents IETP2. b Schematic representation of the processes for determination of the permeability of IETP2-Linker-Cur or Curcumin in mouse cochleae via intravenous administration. c MS traces showing the detection of IETP2-Linker-Cur, Cur-Linker or Cur from collected cochlear lymphatic fluid. To simplify the MS traces, specific cation peaks (m/z: 680.4 for IETP2-Linker-Cur, m/z: 483.4 for Cur-Linker, m/z: 369.3 for Curcumin) were detected for each compound. IETP2-Linker-Cur and Cur-Linker were detected in the cochlear lymphatic fluid from mice injected with IETP2-Linker-Cur. Curcumin was not detected in the cochlear lymphatic fluid from any of the mice
