Table 4 The summary and comparison of PROTACs targeting BCR-ABL
From: PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)
No. | PROTAC | Warhead | E3 ligase |
|---|---|---|---|
1 | GMB-475(82) | Allosteric GNF family compounds | VHL |
2 | GMB-805(83) | Allosteric GNF family compounds | VHL |
3 | P22P(84) | Dasatinib | CRBN |
4 | P19As(85) | Asciminib | CRBN |
5 | P19P(86) | Ponatinib | CRBN |
6 | 87 | GZD824 | CRBN |
7 | SIAIS178(88) | Dasatinib | VHL |
8 | SIAIS056(89) | Dasatinib | CRBN |
9 | SIAIS629050(90) | Dasatinib | CRBN |
10 | SIAIS629051(91) | Dasatinib | CRBN |
11 | BT1(92) | Dasatinib | RNF114 |
12 | Azo-PROTAC-4C(93) | Dasatinib | CRBN |
