Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Targeting fibrosis: mechanisms and clinical trials

Fig. 2

The activation of HSCs regulated by other cells in liver fibrosis. Extracellular components from injured hepatocytes, Kupffer cells, macrophages, NK cells, T and B lymphocytes modulate HSCs activation via various cytokines. LSECs inhibit or promote the activation of HSCs in different conditions. NK cells kill activated HSCs in IFNγ and TRAIL-dependent ways. TRAIL, TNF-related apoptosis-inducing ligand

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