Fig. 5

Functional implications of AASEs. a The number and percentage of genes with each feature (indicated on the y-axis) among the 2081 AASEs-related genes. The dark color in each bar represents the percentage of genes having isoforms that each feature varies. b GO enrichment analysis result for AASEs-related genes. c Heatmap of the correlation coefficients of the AASEs correlated with 14 cancer hallmarks. Each column represents a single AASE and each row depicts the results of the correlation to a single hallmark signature. The color represents the strength and direction of the correlation (red indicating positive; blue indicating negative) of a single AASE with each hallmark. Columns are sorted by hierarchical clustering. Rows are ranked by the total number of AASEs correlates passing statistical criteria for each hallmark. The number of AASEs significantly correlated with each hallmark was represented in the bar chart. d Hive plot depiction of AASEs correlated with 14 cancer hallmarks and the biological processes associated with genes affected by AASEs. All hallmarks-related AASEs are displayed on the left axis. The top seven hallmarks with the most correlated AASEs are represented as nodes on the middle axis. The size of these nodes reflects the number of AASEs correlated with each hallmark. The right axis indicates four summary gene ontology terms. The width of the edges connecting the nodes on the middle axis to the nodes on the right axis is proportional to the −log10 (p value) of the enrichment result. The size of the nodes on the right axis is proportional to the total number of hallmarks associated with each biological process