Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: Multi-omics analysis reveals RNA splicing alterations and their biological and clinical implications in lung adenocarcinoma

Fig. 6

The AASEs and biological characteristics of the three LUAD subtypes. a Box plot showing the AASEs frequency of LUAD samples in each subtype. b Bar plot showing the proportion of the seven AASEs types in each LUAD sample. c AASEs frequency was positively correlated with immune cell infiltration levels. d Kaplan–Meier overall survival curves comparing AASEs frequency high and low subgroups in LUAD. Patients were stratified into high (top 25th percentile) and low (bottom 25th percentile) subgroups based on their AASEs frequency. e Heatmap representing the subtype-specific AASEs in each LUAD subtype. f The subtype-specific biological characteristics of each AASE subtype. g Bar plots showing the stemness index and telomerase activity of each LUAD sample. h, i Heatmap and box plot showing the methylation levels of 719 most variable DNA methylation-specific probes in CpG island promoter regions

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