Fig. 7 | Signal Transduction and Targeted Therapy

Fig. 7

From: Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

Fig. 7

Gut–liver axis in NAFL/NASH. Unhealthy diet, such as high fat and high sugar, induces changes in the intestinal microbiome. This in turn affects alterations in metabolites, such as a decrease in beneficial SFAs and an increase in LPS, ethanol, TMA, etc. The impaired gut barrier allows increased and easier translocation of these dangerous substances to the liver, accelerating the progression of NAFL/NASH. BAs bile acids, SCFAs short-chain fatty acids, LPS lipopolysaccharide, TMA trimethylamine, IAA indole-3-acetic acid

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