Fig. 8 | Signal Transduction and Targeted Therapy

Fig. 8

From: Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

Fig. 8

Stem cell therapy in liver fibrosis. MSCs isolated from different sources, including umbilical cord, bone marrow, placental, adipose tissue, placental, hair follicle, function to improve liver fibrosis. MSCs reduced hepatocyte damage through immune suppressive pathways, which in turn prevents HSC activation. Furthermore, MSCs increased the phagocytosis of hepatocyte debris by changing macrophage polarity, while increasing matrix metalloproteinase synthesis to remodel extracellular matrix. Created with BioRender

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