Fig. 2

Cross-neutralization analysis of eight Spike protein-elicited sera against eight SARS-CoV-2 variants. The NT50 ratios of the tested pseudotyped SARS-CoV-2 variants to the homologous pseudovirus are displayed as a violin plot. The data represent the mean values of three repeated experiments. The dashed line indicates fourfold difference. Data from sera collected after 3 doses of D614G (a), Alpha (b), Beta (c), Gamma (d), Delta (e), Omicron (f), Lambda (g), and Mu (h). One-way ANOVA and Dunnett’s multiple comparisons tests were used for statistical analysis. The significance of the difference of each group compared to the homogenous immunized group is indicated with asterisks