Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: Cross-reactivity of eight SARS-CoV-2 variants rationally predicts immunogenicity clustering in sarbecoviruses

Fig. 6

The key mutation sites of the Omicron BA.1 variant that determine its antigenicity and immunogenic clustering of sarbecoviruses. Sera collected from guinea pigs 28 days after three doses of D614G spike immunization (a/g) or 14 days after the three doses of Omicron spike immunization (c/d) were tested. The column plot shows the NT50 titer ratio of each single or combined mutation to D614G (a/c) or Omicron (b/d). The dashed lines indicate fourfold or tenfold difference. The data represent the mean values of three repeated experiments. e Immunogenic clustering of 25 representative sarbecoviruses, including SARS-CoV, SARS-CoV-2 variants and bat- or pangolin-derived coronaviruses based on the site total escape score and amino acid conservation on RBD. One-way ANOVA and Dunnett’s multiple comparisons test were used for statistical analysis

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