Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery

Fig. 1

Activities of 58G6. a Binding of 58G6 to different RBDs, including SARS-CoV-2 WT, Delta, Omcrion BA.1 and BA.2, as measured by ELISA. b Neutralization of pseudotyped SARS-CoV-2 WT, Delta and Omcrion BA.1 by 58G6. Inhibitory rates of infection were calculated by scanning fluorescent plaques. c Evaluation of the neutralization activity of 58G6 against live SARS-CoV-2 WT and the Delta and Omicron variants. d The affinities of 58G6 for S proteins of SARS-CoV-2, Delta, Omicron BA.1 and Omicron BA.2 measured by BLI. e Binding regions of 58G6. RBDs from WT SARS-CoV-2 and the Alpha, Beta, Gamma, Delta and Omicron variants are aligned. The red lines indicate the binding regions (450–458, 470–495) of 58G6. f Structure of the complex of 58G6 Fab bound onto the SARS-CoV-2 RBD. On the left, the secondary structure elements of the RBD and heavy and light chains of 58G6 Fab are colored green, cyan and violet, respectively. The surface of the RBD is colored green. The mutated residues of the Delta variant are colored blue (middle), while those from the Omicron are colored red (right)

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