Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Lactate metabolism in human health and disease

Fig. 3

Mechanism by which lactylation promotes tumorigenesis. Lactylation leads to tumor immunosuppression by maintaining TAM homeostasis. Lactylation directly promotes the expression of the oncogene YTHDF2 in tumor cells. Lactylation maintains the metabolic homeostasis of tumor cells. Lactylation may lead to tumor immunosuppression and immune escape by inhibiting the function of various immune cells in the TME. HK-1 hexokinase-1; G6PD glucose-6-phosphate dehydrogenase; PKM pyruvate kinase; SDH succinate dehydrogenase; IDH isocitrate dehydrogenase; TCA cycle tricarboxylic acid cycle

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