Table 1 The regulation of lactylation in cell lines and diseases

MCF-7

H3K9,18,23,27,56,122

N/A

Breast cancer16

H4K5,8,12,31,77,91

HeLa

H3K9,18,23,27,79

N/A

Cervical cancer16

H4K5,8,12,16,31,77,91

H2AK11,13,115

H2BK5,11,15,16,20,23,43,85,108,116,120

MEF

N/A

N/A

N/A

HCT116

H3K18

N/A

Colon cancer16

BMDM

H3K14,18,23,27,56

Wound healing 16; inflammation repair 70; tumor cell proliferation; pulmonary fibrosis 72; upregulate ARG1, PDGFA, THBS1, and VEGFA.

N/A

H4K8,12,31,91

H2AK11,115

H2BK5,11,15,16,20,85,108

HepG2

H3K18

N/A

Hepatocellular carcinoma16

HEK293T

H3K18

N/A

N/A

LLC1

H3K18

N/A

Lung cancer 16

B16F10

H3K18

N/A

Cutaneous melanoma16

PIG1

H3K18

N/A

N/A

OCM1/OMM1/MUM2B/CRMM1/2/CM2005.1

H3K18

Tumorigenesis 74; upregulate the oncogene YTHDF2.

Ocular melanoma74

BEAS-2B/A549/H1299

H4

Tumor cell proliferation 76; upregulate SDH and IDH; downregulate HK-1 and PKM.

Non-small cell lung cancer76