Fig. 6
From: Applications of human organoids in the personalized treatment for digestive diseases
The prospect of combining high-technology approaches and digestive organoids. Gene editing and omics (epigenetics, transcriptomics, proteomics, metabolomics, and single-cell sequencing) technologies are used in combination with organoid models to systematically and comprehensively analyze molecular, cellular, and histological changes mediated by gene mutations or environmental interventions. Starting from basic research, the in vivo phenotypes and molecular targets corresponding to organoids under different conditions are continuously explored to guide the selection and testing of clinical treatment strategies
